Deep-Dive Due Diligence AI Generated Probe of Septerna, Inc. Common Stock (SEPN)

Welcome to ScanScor. What you're reading is not just a stock summary -- it's a real-time, AI-generated due diligence session crafted from live news, financial data, insider trading activity, SEC filings, and live market momentum.

These auto-generated reports apply OpenAI's GPT-based analysis engine, guided by tightly structured prompts and expert-level data ingestion. Every insight below was assembled to help you understand the forces behind today's market movers.

Disclaimer: This report is for informational purposes only. It does not constitute financial advice. Always do your own research before making any investment.

Market Score
  40
Price Target
  $8.05
Squeeze Score
  65
Stock Type
  Speculative
Sentiment
  Mixed
Primary Catalyst
  Earnings report
Ethical Rating
  C
Tags
  biotech, high volatility, insider activity, short interest

Septerna Swings Amid High Volatility and Insider Trades

Summary: Septerna has displayed volatile financial performance with a significant quarterly performance drop of -56.68% contrasted by a recent weekly surge of 19.25%. The company has a high short interest which could explain the recent price volatility. Despite growth in revenue over the past five years, the recent negative net income highlights challenges. Insider transactions and substantial institutional ownership indicate mixed confidence levels from those close to company operations.

SEPN_OUT_1 [2025-04-29 07:05:44 -0400] 4346 Bytes | 1161 tokens | Cum: 1161 tkns (14.51% of 8k)
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A volatile market is a logical market. It is 7:05 AM on Tue Apr 29, 2025. Septerna (SEPN) surges from $6.46 to $7.18. Analyze we shall, without fear or favor.

--- COMPANY PROFILE ---
Company: Septerna (SEPN)
IPO: 2024-10-25 (6 Months Ago)
Market Cap: $232,434,254
Shares Outstanding: 44,440,000
Industry: PHARMACEUTICAL PREPARATIONS
Exchange: XNAS
Description: Septerna Inc is a clinical-stage biotechnology company pioneering a new era of G protein-coupled receptor (GPCR) oral small molecule drug discovery powered by a proprietary Native Complex Platform. Its industrial-scale platform aims to unlock the full potential of GPCR therapies. The group discovery and development of a pipeline of product candidates focused initially on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic disease. Its pipeline includes SEP-786 (PTH1R), SEP-631 (MRGPRX2), TSHR, GLP-1R, GIPR, and GCGR.

Here’s a list of headlines for Septerna:

Apr-16-25 09:55AM - Wall Street Analysts Predict a 207.31% Upside in Septerna, Inc. (SEPN): Here's What You Should Know
Mar-31-25 02:34PM - Biotech Stocks Q1 2025 Recap: Winners And Underperformers
Mar-27-25 08:00AM - Septerna Provides Corporate Overview and Reports Fourth Quarter and Full Year 2024 Financial Results
Mar-14-25 11:26AM - Septerna, Inc. (SEPN): Among Top Insider Purchases Last Month
Mar-05-25 06:59PM - Septerna, Inc. (SEPN): Among The Stocks With At Least $30 Million In Insider Spending Recently
Feb-26-25 08:00AM - Septerna to Present at TD Cowen 45th Annual Health Care Conference
Feb-18-25 08:00AM - Septerna Announces Discontinuation of SEP-786 Phase 1 Clinical Trial and Plans to Advance Next-Generation Oral Small Molecule PTH1R Agonist
Feb-14-25 06:45AM - Its not for the faint of heart. How 3 CEOs took their biotechs public
Feb-06-25 07:48AM - Septerna, Inc. (SEPN): Among the Best Rebound Stocks to Invest In Now
Jan-06-25 07:00AM - Septerna Expands Leadership with Appointment of Industry Veteran Gil Labrucherie as Chief Financial Officer
Dec-18-24 08:00AM - Septerna to Present at the 43rd Annual J.P. Morgan Healthcare Conference
Nov-21-24 11:12PM - Septerna, Inc. Reports Q3 2024 Financials and Progress
Nov-20-24 07:00AM - Septerna Reports Third Quarter 2024 Financial Results and Recent Business Highlights
Nov-20-24 07:00AM 05:10AM - Septerna initiated with an Overweight at JPMorgan
Oct-30-24 04:41PM - Septerna Announces Closing of $331.2 Million Upsized Initial Public Offering
Oct-24-24 09:47PM - Septerna Prices Upsized Initial Public Offering

Here's another list of headlines with menu handles.
I will deliver the full text of the following stories when you say their handle.
Just say, for example, B1, B2, etc.

B1 - 2025-02-19T23:00:00Z - Kirby McInerney LLP Announces Investigation Against Septerna, Inc. (SEPN) on Behalf of Investors
B2 - 2024-12-18T13:00:00Z - Septerna to Present at the 43rd Annual J.P. Morgan Healthcare Conference
B3 - 2024-11-20T12:00:00Z - Septerna Reports Third Quarter 2024 Financial Results and Recent Business Highlights

==============
-> THE ROLE FOR AI:
==============

1) You are the **AI analyst-investigator**, and this interaction represents a full **due diligence session** for Septerna (SEPN).
Due diligence includes financial data, insider trading, relevant news, and any SEC filings — and may extend beyond classic fundamentals.
Your task is to identify whether this stock has momentum and potential.

2) I am **ScanScor**, a unified report generator that archives this session as part of our real-time diligence record.

3) You will request information by referencing documents by their code.

4) As the analysis proceeds, your are encouraged to review documents until you feel confident in your judgment.
After seeing 3 sets of news articles, SEC docs, and financials, you'll be prompted to return some data pairs.

5) News articles, SEC filings, and key metrics will be revealed in subsequent prompts.

Stay focused. Gather evidence. Continue until your conclusions are clear.
Restrict all your responses to just 3 tokens until the summary and data pairs at the end.

NEXT: Request a document with its reference code(s), such as:
- `B1`, `B2`, `B3`, etc.
- To load a new set of information and menu options, reply with: `NEX`

SEPN_IN_2 [2025-04-29 07:05:44 -0400] 2 Bytes | 2 tokens | Cum: 1163 tkns (14.54% of 8k)
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B1

SEPN_OUT_3 [2025-04-29 07:05:45 -0400] 860 Bytes | 242 tokens | Cum: 1405 tkns (17.56% of 8k)
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Showing B1 (chunk 1 of 1): B1:
**Kirby McInerney LLP Announces Investigation Against Septerna, Inc. (SEPN) on Behalf of Investors**Date: Unknown DateSource: Unknown SourceURL: https://www.globenewswire.com/news-release/2025/02/19/3029240/937/en/Kirby-McInerney-LLP-Announces-Investigation-Against-Septerna-Inc-SEPN-on-Behalf-of-Investors.htmlKirby McInerney LLP is investigating potential claims against Septerna, Inc. (NASDAQ:SEPN) after the company announced the discontinuation of a clinical trial for its hypoparathyroidism treatment due to unexpected severe cases of elevated unconjugated bilirubin.

Respond with ONLY ONE of the following (3 characters max):
- `MOR` to continue this item
- `NEX` to move to the next set of documents
- `C2`, `S3`, etc. to request another document
**DO NOT SUMMARIZE. DO NOT EXPLAIN.** Wait until all data is presented.

SEPN_IN_4 [2025-04-29 07:05:45 -0400] 3 Bytes | 2 tokens | Cum: 1407 tkns (17.59% of 8k)
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NEX

SEPN_OUT_5 [2025-04-29 07:05:46 -0400] 849 Bytes | 276 tokens | Cum: 1683 tkns (21.04% of 8k)
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We present this news so you can catch the big movers from recently breaking news.
Here's a list of news articles you can literally read just by asking.
Usually the first item is the most important.

A1 - 2025-04-25T11:25:00Z - Septerna Insiders Placed Bullish Bets Worth US$934.3k...
A2 - 2025-04-25T11:25:00Z - Septerna Insiders Placed Bullish Bets Worth US$934.3k...
A3 - 2025-04-23T11:22:06Z - Avoro Capital Advisors LLC Makes New Investment in Septerna, Inc. (NASDAQ:SEPN)...
A4 - 2025-04-22T10:54:48Z - Trv Gp Vi LLC Makes New Investment in Septerna, Inc. (NASDAQ:SEPN)...
A5 - 2025-04-22T10:54:50Z - Trv Gp V LLC Takes Position in Septerna, Inc. (NASDAQ:SEPN)...

Request an article by its reference number. (Ex., "A1" gets the first item)
You may also say NEX to go to the next listing.
Response to this prompt limited to 3 chars.

SEPN_IN_6 [2025-04-29 07:05:46 -0400] 2 Bytes | 2 tokens | Cum: 1685 tkns (21.06% of 8k)
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A1

SEPN_OUT_7 [2025-04-29 07:05:47 -0400] 1181 Bytes | 286 tokens | Cum: 1971 tkns (24.64% of 8k)
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Showing A1 (chunk 1 of 4): A1:
**Septerna Insiders Placed Bullish Bets Worth US$934.3k**Date: 2025-04-25Source: {'uri': 'finance.yahoo.com', 'dataType': 'news', 'title': 'Yahoo! Finance'}URL: https://finance.yahoo.com/news/septerna-insiders-placed-bullish-bets-112500777.htmlOver the last year, a good number of insiders have significantly increased their holdings in Septerna, Inc. (NASDAQ:SEPN). This is encouraging because it indicates that insiders are more optimistic about the company's prospects.

While we would never suggest that investors should base their decisions solely on what the directors of a company have been doing, we do think it is perfectly logical to keep tabs on what insiders are doing.

This technology could replace computers: discover the 20 stocks are working to make quantum computing a reality.

In the last twelve months, the biggest single purchase by an insider was when Director Alan Ezekowi

Respond with ONLY ONE of the following (3 characters max):
- `MOR` to continue this item
- `NEX` to move to the next set of documents
- `C2`, `S3`, etc. to request another document
**DO NOT SUMMARIZE. DO NOT EXPLAIN.** Wait until all data is presented.

SEPN_IN_8 [2025-04-29 07:05:47 -0400] 3 Bytes | 2 tokens | Cum: 1973 tkns (24.66% of 8k)
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NEX

SEPN_OUT_9 [2025-04-29 07:05:48 -0400] 1107 Bytes | 277 tokens | Cum: 2250 tkns (28.12% of 8k)
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This is our list of SEC filings.
If empty, the search returned no recent filings.

S2 - 2025-03-27 8-K Item2.02. Results of Oper and Fin Cond.

On March 27, 2025, Septerna, Inc. announced its financial results and business highlights for the fourth quarter and year ended December 31, 2024. A copy of the press release in connection with the announcement is being f...

S3 - 2025-03-27 10-K Item 7. Mgts Discussion and Analysis of Fin Cond and Results of Oper.

You should read the following discussion and analysis of our financial condition and results of operations together with our audited financial statements and related notes included el...

S6 - 2025-03-03 8-K Item7.01. Regulation FD Disclosure.

Septerna, Inc. (the Company) will be conducting meetings with participants attending the TD Cowen 45 th Annual Health Care Conference during the week of March 3, 2025. A copy of the presentation is furnished as Exhibit 99.1 to this Curr Re...

Request filing by its reference number. (Ex., "S1" gets the first item)
You can say NEX to go to the next listing.
Response limited to 3 chars.

SEPN_IN_10 [2025-04-29 07:05:48 -0400] 2 Bytes | 2 tokens | Cum: 2252 tkns (28.15% of 8k)
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S2

SEPN_OUT_11 [2025-04-29 07:05:49 -0400] 1129 Bytes | 274 tokens | Cum: 2526 tkns (31.57% of 8k)
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Showing S2 (chunk 1 of 1): S2:
Item2.02. Results of Operations and Financial Condition.

On March 27, 2025, Septerna, Inc. announced its financial results and business highlights for the fourth quarter and year ended December 31, 2024. A copy of the press release in connection with the announcement is being furnished as Exhibit 99.1 to this Current Report on Form 8-K.

The information included under Item 2.02 of this Current Report on Form 8-K, including Exhibit 99.1, is being furnished and shall not be deemed filed for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the Exchange Act), or otherwise subject to the liabilities of that section, and shall not be incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as expressly set forth by specific reference in such filing....

Respond with ONLY ONE of the following (3 characters max):
- `MOR` to continue this item
- `NEX` to move to the next set of documents
- `C2`, `S3`, etc. to request another document
**DO NOT SUMMARIZE. DO NOT EXPLAIN.** Wait until all data is presented.

SEPN_IN_12 [2025-04-29 07:05:49 -0400] 3 Bytes | 2 tokens | Cum: 2528 tkns (31.60% of 8k)
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MOR

SEPN_OUT_13 [2025-04-29 07:05:55 -0400] 7269 Bytes | 2040 tokens | Cum: 4568 tkns (57.10% of 8k)
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This is our set of metrics for Septerna.
Please analyze the numbers.

+---------------------+-----------------------+-------------------------+------------------------+
| Volume: 217,088 | Perf Month: 11.29% | Option/Short: Yes / Yes | Sales Y/Y TTM: - |
+---------------------+-----------------------+-------------------------+------------------------+
| Avg Volume: 520.38K | Perf Quarter: -56.68% | Short Float: 12.50% | ROE: - |
+---------------------+-----------------------+-------------------------+------------------------+
| Rel Volume: 0.42 | Index: RUT | Short Ratio: 6.43 | ROI: - |
+---------------------+-----------------------+-------------------------+------------------------+
| RSI (14): 58.73 | Market Cap: 311.10M | Short Interest: 3.34M | Sales Surprise: 41.33% |
+---------------------+-----------------------+-------------------------+------------------------+
| ATR (14): 0.58 | Shs Outstand: 44.42M | Beta: - | EPS Surprise: 7.69% |
+---------------------+-----------------------+-------------------------+------------------------+
| SMA20: 20.04% | Shs Float: 26.75M | Sales Q/Q: - | P/E: - |
+---------------------+-----------------------+-------------------------+------------------------+
| SMA50: 13.62% | Inst Own: 68.69% | Sales past 5Y: 305.96% | Earnings: Mar 27 BMO |
+---------------------+-----------------------+-------------------------+------------------------+
| SMA200: -53.55% | Insider Own: 39.80% | Employees: 75 | |
+---------------------+-----------------------+-------------------------+------------------------+
| Perf Week: 19.25% | Insider Trans: 43.78% | Debt/Eq: 0.06 | |
+---------------------+-----------------------+-------------------------+------------------------+

The next section covers any insider trading by Septerna officers or majority shareholders (if available).

Inside Trans: Septerna, Inc. (SEPN) by Finer Jeffrey (CEO and President) on 2025-04-02
- Common Stock: 50000 shares at $2.76 (D)
- Common Stock: 5000 shares at $2.76 (D)
- Stock Option (Right to Buy): 50000 shares at $0 (D)
- Stock Option (Right to Buy): 5000 shares at $0 (D)

Inside Trans: Septerna, Inc. (SEPN) by Ezekowitz Alan (Unknown Title) on 2025-03-07
- Common Stock: 13319 shares at $6.9277 (D)

Inside Trans: Septerna, Inc. (SEPN) by Ezekowitz Alan (Unknown Title) on 2025-03-04
- Common Stock: 7491 shares at $6.3468 (D)
- Common Stock: 37835 shares at $5.8216 (D)
- Common Stock: 41355 shares at $6 (D)

Inside Trans: Septerna, Inc. (SEPN) by Labrucherie Gil M (Chief Financial Officer) on 2025-02-25
- Common Stock: 6282 shares at $5.59 (I)
- Common Stock: 3718 shares at $5.85 (I)

Inside Trans: Septerna, Inc. (SEPN) by Finer Jeffrey (CEO and President) on 2025-02-25
- Common Stock: 10000 shares at $5.6765 (D)
- Common Stock: 4000 shares at $5.6989 (D)
- Common Stock: 3000 shares at $5.8 (D)

Inside Trans: Septerna, Inc. (SEPN) by Third Rock Ventures VI, L.P. (Unknown Title) on 2025-02-24
- Common Stock: 18861 shares at $5.999 (D)

Inside Trans: Septerna, Inc. (SEPN) by Third Rock Ventures VI, L.P. (Unknown Title) on 2025-02-20
- Common Stock: 612674 shares at $5.92 (D)
- Common Stock: 427668 shares at $5.94 (D)

[Company Financial Summary]
[Company Details]
Name: N/A
Market Cap: N/A
Shares Outstanding: N/A
Sector: N/A

[Financial Statements - Latest Quarter]
Total Assets: N/A
Total Liabilities: N/A
Total Equity: N/A
Revenue (Quarter): {'value': 1075000.0, 'unit': 'USD', 'label': 'Revenues', 'order': 100}
Net Income: {'value': -71798000.0, 'unit': 'USD', 'label': 'Net Income/Loss', 'order': 3200}
Earnings Per Share (EPS): N/A

[Price Metrics - Last 30 Days]
Latest Close: 7
Average Volume: 238414.3
30-Day High: 7
30-Day Low: 5.02

[Detailed Financials: TTM 2024]
- Total Assets: $456,554,000.00
- Total Liabilities: $36,507,000.00
- Total Equity: $420,047,000.00
- Current Assets: $356,824,000.00
- Current Liabilities: $12,849,000.00

[Income Statement: TTM 2024]
- Revenue: $1,075,000.00
- Net Income: $-71,798,000.00
- Gross Profit: N/A
- Operating Income: $-80,823,000.00
- Earnings Per Share (EPS): -7.26

[Cash Flow Statement: TTM 2024]
- Net Cash Flow: $149,713,000.00

[Detailed Financials: FY 2024]
- Total Assets: $456,554,000.00
- Total Liabilities: $36,507,000.00
- Total Equity: $420,047,000.00
- Current Assets: $356,824,000.00
- Current Liabilities: $12,849,000.00

[Income Statement: FY 2024]
- Revenue: $1,075,000.00
- Net Income: $-71,798,000.00
- Gross Profit: N/A
- Operating Income: $-80,823,000.00
- Earnings Per Share (EPS): -7.26

[Cash Flow Statement: FY 2024]
- Net Cash Flow: $149,713,000.00
==== END OF FINANCIAL REPORT ====

You are now requested to write a summary analysis of Septerna (SEPN).

Please complete the report using the exact format:
FIELD[value]

1) BRIEF_SUMMARY[]
One well-worded paragraph summarizing your findings about Septerna.

2) MARKET_SCORE[]
This conversation was initiated because SEPN is currently experiencing upward price and volume movement.
Estimate a number between 1–100 based on the likelihood of a continued upward price move for SEPN.
Weigh relevant data — news, filings, fundamentals, and metrics — and assign appropriate weight.

3) PRICE_TARGET[]
Suggest a price, based on all prior evidence and past price behavior, SEPN could reach in the current or upcoming trading sessions (1–5 days).
For example, if you expect SEPN to increase 50% from its current price of $0.00, say: PRICE_TARGET[0.0]

4) AI_RPT_HEADLINE[]
Write a thought-provoking 8–12 word headline summarizing this report.

5) SQUEEZE_POTENTIAL[]
Give a score from 1 to 100 representing the potential for this stock to become an active short squeeze play.
Be honest and unbiased. Consider short interest/float, price movement, volume, news strength, and volatility potential.

6) TAGS[]
List 3–6 comma-separated tags (e.g., biotech, earnings beat, squeeze setup)

7) STOCK_TYPE[]
Choose the most accurate classification: growth, value, turnaround, hype, squeeze, dividend, speculative, or other.

8) PRIMARY_CATALYST[]
e.g., earnings report, FDA approval, partnership, etc.

9) SENTIMENT[]
bullish, bearish, neutral, or mixed

10) IMPROVEMENT_SUGGESTION[]
If you believe some key info was missing, state what would have significantly improved your analysis of Septerna.

11) ETHICAL_RATING[]
Rate Septerna’s alignment with long-term shareholder interests, using a letter grade from A (high alignment) to F (low alignment).
Base this on actions such as insider buying/selling, share dilution, follow-through on public statements, and compensation practices.

12) UPCOMING_CATALYST[]
Specify any upcoming events you expect would be a catalyst affecting the share-price of Septerna.
Provide any reasons you can use to support it.

Return only: FIELD[value] for each of the above 12 questions.
Respond with all data pairs. Take your best guess if you have to, but don't leave blank items.
Do not explain your answers. Return only the required fields in the exact format shown.

Finally, thank you for participating!

SEPN_IN_14 [2025-04-29 07:05:55 -0400] 1067 Bytes | 224 tokens | Cum: 4792 tkns (59.90% of 8k)
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BRIEF_SUMMARY[Septerna has displayed volatile financial performance with a significant quarterly performance drop of -56.68% contrasted by a recent weekly surge of 19.25%. The company has a high short interest which could explain the recent price volatility. Despite growth in revenue over the past five years, the recent negative net income highlights challenges. Insider transactions and substantial institutional ownership indicate mixed confidence levels from those close to company operations.]

MARKET_SCORE[40]

PRICE_TARGET[8.05]

AI_RPT_HEADLINE[Septerna Swings Amid High Volatility and Insider Trades]

SQUEEZE_POTENTIAL[65]

TAGS[biotech, high volatility, insider activity, short interest]

STOCK_TYPE[speculative]

PRIMARY_CATALYST[earnings report]

SENTIMENT[mixed]

IMPROVEMENT_SUGGESTION[More detailed recent quarterly financials and future financial projections would enhance analysis.]

ETHICAL_RATING[C]

UPCOMING_CATALYST[Next earnings report on Mar 27 BMO could be a significant price catalyst due to potential surprises in financial performance.]

SEPN_IN_15 [2025-04-29 07:05:55 -0400] 126 Bytes | 29 tokens | Cum: 4821 tkns (60.26% of 8k)
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[2025-04-29 07:05:55] # Analysis Completed
Elapsed Time: 11.52 seconds




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