Alumis and Kaken Pharmaceutical have signed a partnership and licensing agreement to develop, manufacture, and commercialize Alumis's product ESK-001 for dermatological uses in Japan. There is an option to extend the license to gastrointestinal and rheumatological conditions. Kaken will pay Alumis $40 million in upfront and near-term co-development payments from 2025 to 2026. Alumis could also earn an additional $140 million depending on milestone achievements and field option fees. Kaken will lead the clinical development of the product.

Progress Software Corporation's shares increased significantly during Tuesday's trading session following the announcement of its impressive quarterly financial results. The company reported earnings per share of $1.31, surpassing the analyst consensus estimate of $1.06. Additionally, Progress Software reported quarterly sales of $238.01 million, which also exceeded the analyst consensus estimate of $235.63 million.

Alumis has reported robust financial results for 2024, highlighting advancements in its late-stage pipeline of oral TYK2 inhibitors for immune-mediated diseases. Additionally, Alumis has announced a merger with ACELYRIN, an agreement that is expected to result in a combined entity possessing a distinct portfolio and improved financial flexibility.

The document refers to a recent press release by Alumis Inc. which discloses its financial results for the year ending on December 31, 2024. The specifics of the financial results are not detailed within this section, but a copy of the press release is attached as Exhibit 99.1. It is also mentioned that the information in this section and Exhibit 99.1 is not filed for the purposes of Section 18 of the Securities Exchange Act of 1934, meaning it is not subject to the liabilities of that section. It also cannot be incorporated by reference in any filing by the company under the Securities Act of 1933 or the Exchange Act, unless explicitly specified in such a filing.

1) Brief Summary: The company has experienced a significant increase in performance over the past month, with a performance increase of 81.48%. However, the company's return on equity (ROE) and return on investment (ROI) are both negative, indicating that the company is not utilizing its equity and investments effectively to generate profits. The company's sales have not increased over the past 5 years, and it's not clear if there is any growth in revenues in the latest quarter. Additionally, the company has a high relative volume of 4.66, indicating that the stock is being actively traded. However, the company's short float is 12.08%, suggesting that a significant number of investors are betting that the stock price will fall. 2) MARKET_SCORE: Given the mixed signals in the company's financial metrics, I would assign a MARKET_SCORE: 50

implying a 50% likelihood of an upward move. 3) PRICE_TARGET: Given the uncertainty in the company's financial performance, I would suggest a conservative price target. If the current price is $8.4, I would add 10%. Thus, PRICE_TARGET: $9.24

. 4) AI_RPT_HEADLINE: "Company's High Trading Volume Amid Negative Returns Raises Questions"

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